5-MeO-DMT: Meeting God
with the help of a magical toad
From the defensive glands of the Sonoran Desert Toad, Bufo Alvarius, comes a remarkable molecule that, when inhaled by humans, can produce a direct experience of blissful union with the divine.
Popularly referred to as Bufo, this is 5-MeO-DMT, which stands for 5-methoxy-N,N-dimethyltryptamine or O-methyl-bufotenin. We are so pleased that we have found an ideal location for serving the molecule in the heart of the Sonoran Desert. To further honor and protect this marvelous toad, we only serve the human-derived version of the molecule. The synthetic molecule is sometimes called Jaguar, though on this website and in our interactions with you we may refer to it as Five or the molecule.
5-MeO-DMT is possibly the most powerful psychedelic known to humans, and is also often referred to as an entheogen, from the Ancient Greek where entheos means “full of the god” and genesthai means “to come into being.”
Five is found in a wide variety of plant species, and also in human body fluids, as well as being synthesized in the human pineal gland and retina, but none of these offer sufficient strength to produce a psychoactive experience.
The effects of 5-MeO-DMT happen swiftly, with onset in seconds after inhalation and duration of typically 10 to 45 minutes, although it can be somewhat different with other routes of administration.
Five’s mind-expanding properties lead to profound spiritual experiences for most of the people who engage with it. In addition, recent scientific studies conducted by Johns Hopkins University and others have identified 5-MeO-DMT as an effective treatment for depression, anxiety, and PTSD, as participants report immediate and sustained improvements in these challenges, as well as overall improvement in life satisfaction. Immediately after a Five experience, there is a substantial increase in neuroplasticity and neurogenesis, making new healthier patterns of thinking and self-care easier to establish.
Five can be deeply healing for trauma and emotional pain, while it can also profoundly enhance our spiritual pursuits. For many individuals, 5-MeO-DMT provides the experience that they have been seeking their entire lives.
Dosage
One of many reasons for working with the human-synthesized 5-MeO-DMT molecule (instead of the Toad secretion) is that dosing is more accurate and reliable. We will discuss with you individually beforehand what your previous experience has been with Five and/or other psychedelics to help determine the best dosage for your experience, and we will also always let you know in advance what amount we think is going to produce the most meaningful effect. When inhaling the molecule, we may recommend starting with a low “handshake” dose, moving to a “hug” dose, and then, if it feels right for you, moving to a “full release” dose. We welcome any of your questions!
Routes of Administration
The most common method of beginning a Five experience is inhaling the vapor of the heated molecule powder in a pipe or “lamp.” We will show you the mechanism and allow you to hold it beforehand, and we will guide you on the best practice for inhaling. This approach produces the most intense and fast-acting experience, depending on the dosage. Alternatively, Five can be inhaled through your nostrils (insufflation), or self-inserted as a suppository. These methods produce less abrupt and longer lasting experiences, which can have their own powerful effects. Please feel free to ask us any questions you may have about these different methods!
Additional Rounds
As described above, for ceremonies when you are inhaling 5-MeO-DMT, we may recommend that you begin with a lower handshake dose, possibly moving up to a hug dose, and then proceeding to a third full release dose. Or it could be other variations, depending on how the experience is progressing for you. We will offer our recommendation before beginning. Once you are in the experience at any level, you may not want or be able to form spoken words to let us know you are ready for your second or third dose, so we ask that you use the more symbol, as shown above, where you put your fingers together on both hands and tap them together. We will demonstrate the signal just before starting. Of course, if at any point you are able to speak, please never hesitate to ask for whatever you need, whether it’s about dosing, or needing a blanket, or anything else coming up.